![]() In conclusion, a moderate radiation dose escalation (> 60 Gy) was an independent predictor for longer OS in GBM patients. Following detailed statistical analysis, a moderate radiation dose escalation (> 60 Gy) was found as an independent factor affecting OS in GBM patients. The escalated dose (HR = 0.47) and a larger radiation volume (HR = 0.76) were identified as predictors for better OS. 12.5 months, p 70 (HR = 1.55), diagnosis after 2010 (HR = 1.42), and a larger radiation volume (≥ 250ml HR = 0.81) were predictors of PFS. 7.9 months, p = 0.01 for log-rank test), and a longer median OS was also longer in the escalation group (33.8 vs. The escalated group had a longer median PFS (15.4 vs. Fifteen (18%) patients received an escalated dose boost >60.0 Gy. The radiation dose ranged from 50.0 Gy to 66.6 Gy, but their treatment volumes were similar to the others. From our cancer registry database, 142 GBM patients were identified, and 84 of them fit the inclusion criteria. We also affirmed the results using Cox regression with least absolute shrinkage and selection operator (LASSO) approach. The progression-free survival (PFS) and overall survival (OS) were compared between the two dose groups, and independent factors for survival were analyzed through Cox proportional hazard model. They were identified from the cancer registry database and followed up from the date of diagnosis to October 2018. ![]() We retrospectively reviewed the medical records of primary GBM patients diagnosed between 20 in two referral hospitals in Taiwan. We conducted a study to evaluate the survival outcomes between a standard dose (≤ 60 Gy) and moderate radiation dose escalation (>60 Gy), and to identify prognostic factors for GBM. ![]() However, prospective studies including more patients with more information, such as molecular markers and completeness of resection, are needed to confirm our findings.Ībstract = "Glioblastoma (GBM) has the highest fatality rate among primary malignant brain tumors and typically tends to recur locally just adjacent to the original tumor site following surgical resection and adjuvant radiotherapy. ![]() Glioblastoma (GBM) has the highest fatality rate among primary malignant brain tumors and typically tends to recur locally just adjacent to the original tumor site following surgical resection and adjuvant radiotherapy. ![]()
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